Diseño de un sistema fotovoltaico para suministrar energía eléctrica al caserío Anexo Perlas del Altiplano Juliaca – Puno

A través de esta propuesta de investigación es abastecer de energía eléctrica a las viviendas y planta de bombeo del Caserío Anexo Perlas del Altiplano del distrito Juliaca a través de un diseño sistema fotovoltaico para suministrar energía eléctrica al Caserío Anexo Perlas del Altiplano Juliaca – Puno. El tipo de metodología de investigación actual utilizada es de investigación aplicada en el Caserío Anexo Perlas del Altiplano; la toma de datos se realizó en el Caserío Anexo Perlas del Altiplano, para ello se realizaron encuestas a los pobladores del Caserío Anexo Perlas del Altiplano. Adicionalmente, Se utilizó el formulario de recolección de datos y la observación directa. La información de consumo medio diario se recolectó, mediante una encuesta realizada a los pobladores del Caserío Anexo Perlas del Altiplano. y la toma de datos de radiación solar mediante el equipo de medición Solarimetro, cabe mencionar también que el caserío de Anexo Perlas del Altiplano se diseñara una planta de bombeo de agua a la cual también se le realizo el diseño y calculo respectivo. Esto permitió el cálculo de la cantidad de energía necesaria, así como la predicción de su crecimiento a lo largo del tiempo. El estudio actual es práctico, sostenible y garantiza que los pobladores finales recibirán un servicio de energía de alta calidad sobre todo eco amigable. La implementación de este proyecto muestra a las generaciones futuras cómo utilizar la radiación solar de la manera más eficiente posible, generar más energía más producción de energía y en consecuencia tener la plena convicción de la protección del medio ambiente

Lily Day, Wednesday, March 4, 1964

Comments on past research in Ohio on Lilies / D. C. Kiplinger -- Lily investigations / Abdel-Alim M. Shoushan -- Further studies on causes and control of leaf scorch in Croft Easter lily / N. W. Stuart, William Skou, and D. C. Kiplinger -- Fertilizer and lime affect amount of leaf scorch in Croft Easter lilies / Neil W. Stuart, K. S. Nelson and D. C. Kiplinger -- Comparative development of Ace and Nellie White lilies / Dennis Rider and D. C. Kiplinger -- Experiments with potted lilies, 1961-1962 / D. C. Kiplinger, Robert O. Miller, Howard Jones, and Dennis Rider -- Lily culture and timing for Easter, 1964 / D. C. Kiplinger and Robert O. Miller -- High temperature treatment of Easter lily bulbs / Robert O. Miller and D. C. Kiplinger -- An investigation of causes of variation in the growth of commercial and experimental lilies / Robert O. Miller and D. C. Kiplinger -- Applying terraclor with or without dexon / D. C. Kiplinger, Robert O. Miller and Leonard J. Her

The Star Formation History and Extended Structure of the Hercules Milky Way Satellite

We present imaging of the recently discovered Hercules Milky Way satellite and its surrounding regions to study its structure, star formation history and to thoroughly search for signs of disruption. We robustly determine the distance, luminosity, size and morphology of Hercules utilizing a bootstrap approach to characterize our uncertainties. We derive a distance to Hercules of $133 \pm 6$ kpc via a comparison to empirical and theoretical isochrones. As previous studies have found, Hercules is very elongated, with $\epsilon=0.67\pm0.03$ and a half light radius of $r_{h} \simeq 230$ pc. Using the color magnitude fitting package StarFISH, we determine that Hercules is old ($>12$ Gyr) and metal poor ($[Fe/H]\sim-2.0$), with a spread in metallicity, in agreement with previous spectroscopic work. We infer a total absolute magnitude of $M_V=-5.3\pm0.4$. Our innovative search for external Hercules structure both in the plane of the sky and along the line of sight yields some evidence that Hercules is embedded in a larger stream of stars. A clear stellar extension is seen to the Northwest with several additional candidate stellar overdensities along the position angle of Hercules out to $\sim$35' ($\sim$1.3 kpc). While the association of any of the individual stellar overdensities with Hercules is difficult to determine, we do show that the summed color magnitude diagram of all three is consistent with Hercules' stellar population. Finally, we estimate that any change in the distance to Hercules across its face is at most $\sim$6 kpc; and the data are consistent with Hercules being at the same distance throughout.Comment: 50 pages, 15 figures, submitted to the Astrophysical Journa

Endocrine regulation of predator-induced phenotypic plasticity

Elucidating the developmental and genetic control of phenotypic plasticity remains a central agenda in evolutionary ecology. Here, we investigate the physiological regulation of phenotypic plasticity induced by another organism, specifically predator-induced phenotypic plasticity in the model ecological and evolutionary organism Daphnia pulex. Our research centres on using molecular tools to test among alternative mechanisms of developmental control tied to hormone titres, receptors and their timing in the life cycle. First, we synthesize detail about predator-induced defenses and the physiological regulation of arthropod somatic growth and morphology, leading to a clear prediction that morphological defences are regulated by juvenile hormone and life-history plasticity by ecdysone and juvenile hormone. We then show how a small network of genes can differentiate phenotype expression between the two primary developmental control pathways in arthropods: juvenoid and ecdysteroid hormone signalling. Then, by applying an experimental gradient of predation risk, we show dose-dependent gene expression linking predator-induced plasticity to the juvenoid hormone pathway. Our data support three conclusions: (1) the juvenoid signalling pathway regulates predator-induced phenotypic plasticity; (2) the hormone titre (ligand), rather than receptor, regulates predator-induced developmental plasticity; (3) evolution has favoured the harnessing of a major, highly conserved endocrine pathway in arthropod development to regulate the response to cues about changing environments (risk) from another organism (predator)

Variable number of tandem repeat polymorphisms of the interleukin-1 receptor antagonist gene IL-1RN: a novel association with the athlete status

<p>Abstract</p> <p>Background</p> <p>The interleukin-1 (IL-1) family of cytokines is involved in the inflammatory and repair reactions of skeletal muscle during and after exercise. Specifically, plasma levels of the IL-1 receptor antagonist (IL-1ra) increase dramatically after intense exercise, and accumulating evidence points to an effect of genetic polymorphisms on athletic phenotypes. Therefore, the IL-1 family cytokine genes are plausible candidate genes for athleticism. We explored whether IL-1 polymorphisms are associated with athlete status in European subjects.</p> <p>Methods</p> <p>Genomic DNA was obtained from 205 (53 professional and 152 competitive non-professional) Italian athletes and 458 non-athlete controls. Two diallelic polymorphisms in the IL-1β gene (<it>IL-1B</it>) at -511 and +3954 positions, and a variable number tandem repeats (VNTR) in intron 2 of the IL-1ra gene (<it>IL-1RN</it>) were assessed.</p> <p>Results</p> <p>We found a 2-fold higher frequency of the <it>IL-1RN </it>1/2 genotype in athletes compared to non-athlete controls (OR = 1.93, 95% CI = 1.37-2.74, 41.0% vs. 26.4%), and a lower frequency of the 1/1 genotype (OR = 0.55, 95% CI = 0.40-0.77, 43.9% vs. 58.5%). Frequency of the <it>IL-1RN </it>2/2 genotype did not differ between groups. No significant differences between athletes and controls were found for either -511 or +3954 <it>IL-1B </it>polymorphisms. However, the haplotype (-511)C-(+3954)T-(VNTR)2 was 3-fold more frequent in athletes than in non-athletes (OR = 3.02, 95% CI = 1.16-7.87). Interestingly, the <it>IL-1RN </it>1/2 genotype was more frequent in professional than in non-professional athletes (OR = 1.92, 95% CI = 1.02-3.61, 52.8% vs. 36.8%).</p> <p>Conclusions</p> <p>Our study found that variants at the IL-1ra gene associate with athletic status. This confirms the crucial role that cytokine IL-1ra plays in human physical exercise. The VNTR <it>IL-1RN </it>polymorphism may have implications for muscle health, performance, and/or recovery capacities. Further studies are needed to assess these specific issues. As VNTR <it>IL-1RN </it>polymorphism is implicated in several disease conditions, athlete status may constitute a confounding variable that will need to be accounted for when examining associations of this polymorphism with disease risk.</p

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure &lt; 100 mmHg (n = 1127), estimated glomerular filtration rate &lt; 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

An Iwahori-Whittaker model for the Satake category

International audienceIn this paper we prove, for G a connected reductive algebraic group satisfying a technical assumption, that the Satake category of G (with coefficients in a finite field, a finite extension of Q_l, or the ring of integers of such a field) can be described via Iwahori-Whittaker perverse sheaves on the affine Grassmannian. As an application, we confirm a conjecture of Juteau-Mautner-Williamson describing the tilting objects in the Satake category